Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy

Paul A. Bottomley

doi:10.1126/science.4023711

Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved ³¹P NMR spectroscopy

Paul A. Bottomley

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative concentrations of high-energy phosphate metabolites have been recorded noninvasively from the human heart in vivo. Spectral data were spatially localized by combining a pulsed magnetic field gradient with surface NMR excitation-detection coils. The location of the selected spectral region was determined by conventional proton NMR imaging immediately before examination by phosphorus-31 NMR spectroscopy.

Original language	English (US)
Pages (from-to)	769-772
Number of pages	4
Journal	Science
Volume	229
Issue number	4715
DOIs	https://doi.org/10.1126/science.4023711
State	Published - 1985
Externally published	Yes

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title = "Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy",

abstract = "Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative concentrations of high-energy phosphate metabolites have been recorded noninvasively from the human heart in vivo. Spectral data were spatially localized by combining a pulsed magnetic field gradient with surface NMR excitation-detection coils. The location of the selected spectral region was determined by conventional proton NMR imaging immediately before examination by phosphorus-31 NMR spectroscopy.",

author = "Bottomley, {Paul A.}",

year = "1985",

doi = "10.1126/science.4023711",

language = "English (US)",

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AB - Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative concentrations of high-energy phosphate metabolites have been recorded noninvasively from the human heart in vivo. Spectral data were spatially localized by combining a pulsed magnetic field gradient with surface NMR excitation-detection coils. The location of the selected spectral region was determined by conventional proton NMR imaging immediately before examination by phosphorus-31 NMR spectroscopy.

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DO - 10.1126/science.4023711

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ER -

Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved ³¹P NMR spectroscopy

Abstract

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