TY - JOUR
T1 - Noncontrast assessment of blood–brain barrier permeability to water
T2 - Shorter acquisition, test–retest reproducibility, and comparison with contrast-based method
AU - Lin, Zixuan
AU - Jiang, Dengrong
AU - Liu, Dapeng
AU - Li, Yang
AU - Uh, Jinsoo
AU - Hou, Xirui
AU - Pillai, Jay J.
AU - Qin, Qin
AU - Ge, Yulin
AU - Lu, Hanzhang
N1 - Funding Information:
This work was supported by the National Institutes of Health (NIH), grants R01 AG064792, R01 NS106711, R01 NS106702, P41 EB015909, RF1 NS110041, S10 OD021648, and the American Heart Association (AHA), grant 19PRE34380371
Publisher Copyright:
© 2021 International Society for Magnetic Resonance in Medicine
PY - 2021/7
Y1 - 2021/7
N2 - Purpose: Assessment of the blood–brain barrier (BBB) permeability without the need for contrast agent is desirable, and the ability to measure the permeability to small molecules such as water may further increase the sensitivity in detecting diseases. This study proposed a time-efficient, noncontrast method to measure BBB permeability to water, evaluated its test–retest reproducibility, and compared it with a contrast agent–based method. Methods: A single-delay water extraction with phase-contrast arterial spin tagging (WEPCAST) method was devised in which spatial profile of the signal along the superior sagittal sinus was used to estimate bolus arrival time, and the WEPCAST signal at the corresponding location was used to compute water extraction fraction, which was combined with global cerebral blood flow to estimate BBB permeability surface area product to water. The reliability of WEPCAST sequence was examined in terms of intrasession, intersession, and inter-vendor (Philips [Ingenia, Best, the Netherlands] and Siemens [Prisma, Erlangen, Germany]) reproducibility. Finally, we compared this new technique to a contrast agent–based method. Results: Single-delay WEPCAST reduced the scan duration from approximately 20 min to 5 min. Extract fraction values estimated from single-delay WEPCAST showed good consistency with the multi-delay method (R = 0.82, P =.004). Group-averaged permeability surface area product values were found to be 137.5 ± 9.3 mL/100 g/min. Intrasession, intersession, and inter-vendor coefficient of variation of the permeability surface area product values were 6.6 ± 4.5%, 6.9 ± 3.7%, and 8.9 ± 3.0%, respectively. Finally, permeability surface area product obtained from WEPCAST MRI showed a significant correlation with that from the contrast-based method (R =.73, P =.02). Conclusion: Single-delay WEPCAST MRI can measure BBB permeability to water within 5 min with an intrasession, intersession, and inter-vendor test–retest reproducibility of 6% to 9%. This method may provide a useful marker of BBB breakdown in clinical studies.
AB - Purpose: Assessment of the blood–brain barrier (BBB) permeability without the need for contrast agent is desirable, and the ability to measure the permeability to small molecules such as water may further increase the sensitivity in detecting diseases. This study proposed a time-efficient, noncontrast method to measure BBB permeability to water, evaluated its test–retest reproducibility, and compared it with a contrast agent–based method. Methods: A single-delay water extraction with phase-contrast arterial spin tagging (WEPCAST) method was devised in which spatial profile of the signal along the superior sagittal sinus was used to estimate bolus arrival time, and the WEPCAST signal at the corresponding location was used to compute water extraction fraction, which was combined with global cerebral blood flow to estimate BBB permeability surface area product to water. The reliability of WEPCAST sequence was examined in terms of intrasession, intersession, and inter-vendor (Philips [Ingenia, Best, the Netherlands] and Siemens [Prisma, Erlangen, Germany]) reproducibility. Finally, we compared this new technique to a contrast agent–based method. Results: Single-delay WEPCAST reduced the scan duration from approximately 20 min to 5 min. Extract fraction values estimated from single-delay WEPCAST showed good consistency with the multi-delay method (R = 0.82, P =.004). Group-averaged permeability surface area product values were found to be 137.5 ± 9.3 mL/100 g/min. Intrasession, intersession, and inter-vendor coefficient of variation of the permeability surface area product values were 6.6 ± 4.5%, 6.9 ± 3.7%, and 8.9 ± 3.0%, respectively. Finally, permeability surface area product obtained from WEPCAST MRI showed a significant correlation with that from the contrast-based method (R =.73, P =.02). Conclusion: Single-delay WEPCAST MRI can measure BBB permeability to water within 5 min with an intrasession, intersession, and inter-vendor test–retest reproducibility of 6% to 9%. This method may provide a useful marker of BBB breakdown in clinical studies.
KW - WEPCAST
KW - arterial spin labelling
KW - blood–brain barrier
KW - permeability
KW - reproducibility
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U2 - 10.1002/mrm.28687
DO - 10.1002/mrm.28687
M3 - Article
C2 - 33559214
AN - SCOPUS:85100756956
SN - 0740-3194
VL - 86
SP - 143
EP - 156
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 1
ER -