Nonclassical symptoms of primary hyperparathyroidism and their response to parathyroidectomy

Gillian Alex, Lilah Morris, Janice Pasieka, Nancy Perrier

Research output: Contribution to journalComment/debatepeer-review


An estimated 100,000 new patients are diagnosed with primary hyperparathyroidism (PHPT) each year in the United States.1 In the past, patients with PHPT typically presented with "stones, bones, abdominal groans, and psychic moans" but today patients often present with more subtle symptoms and physiologic changes associated with earlier stages of disease. Patients without the classic symptoms of PHPTare often referred to as "asymptomatic." These patients frequently pose a conundrum for clinicians. Uncertainties remain as to which symptoms truly represent PHPTand which are related to comorbidities or the aging process. To address these uncertainties, we review most recent literature regarding the nonclassical manifestations of PHPT and their response to parathyroidectomy.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalAmerican Surgeon
Issue number4
StatePublished - Apr 2013
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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