TY - JOUR
T1 - Noncancerous Genitourinary Conditions as a Public Health Priority
T2 - Conceptualizing the Hidden Burden
AU - Brady, Sonya S.
AU - Bavendam, Tamara G.
AU - Bradway, Christine K.
AU - Conroy, Britt
AU - Dowling-Castronovo, Annemarie
AU - Epperson, Cynthia Neill
AU - Hijaz, Adonis K.
AU - Hsi, Ryan S.
AU - Huss, Karen
AU - Kim, Michelle
AU - Lazar, Jason
AU - Lee, Richard K.
AU - Liu, Christine K.
AU - Loizou, Christine N.
AU - Miran, Saadia
AU - Mody, Lona
AU - Norton, Jenna M.
AU - Reynolds, William Stuart
AU - Sutcliffe, Siobhan
AU - Zhang, Nicole
AU - Hokanson, James A.
N1 - Funding Information:
Dr. Hokanson's work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01DK121866). Dr. Hsi's work was supported by NIDDK (R21DK127075). Dr. Liu's work was supported by the Boston University School of Medicine (Department of Medicine Career Investment Award) and the National Institute of Aging (1K23AG057813). Dr. Reynolds’ work was supported by NIDDK (1K23DK103910). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, NIDDK, or the National Institute of Nursing Research. Financial and Personal Disclosures: C. Neill Epperson: Asarina Pharma (advisory board); Sage Therapeutics (consultant, advisory board, site principle investigator Sage 217-PPD-301 and Sage 547-PPD-304). Adonis K. Hijaz: Collamedix Inc. (equity) and Astellas (speaker). Christine K. Liu: AgeBold (consultant). The remaining authors declare that they have no relevant financial interests. Declaration of Competing Interest: There are no reported financial or personal relationships that could bias this work.
Funding Information:
Dr. Hokanson's work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ( K01DK121866 ). Dr. Hsi's work was supported by NIDDK ( R21DK127075 ). Dr. Liu's work was supported by the Boston University School of Medicine (Department of Medicine Career Investment Award) and the National Institute of Aging ( 1K23AG057813 ). Dr. Reynolds’ work was supported by NIDDK ( 1K23DK103910 ). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, NIDDK, or the National Institute of Nursing Research.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/8
Y1 - 2022/8
N2 - Objective: To provide a conceptual framework to guide investigations into burdens of noncancerous genitourinary conditions (NCGUCs), which are extensive and poorly understood. Methods: The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop of diverse, interdisciplinary researchers and health professionals to identify known and hidden burdens of NCGUCs that must be measured to estimate the comprehensive burden. Following the meeting, a subgroup of attendees (authors of this article) continued to meet to conceptualize burden. Results: The Hidden Burden of Noncancerous Genitourinary Conditions Framework includes impacts across multiple levels of well-being and social ecology, including individual (ie, biologic factors, lived experience, behaviors), interpersonal (eg, romantic partners, family members), organizational/institutional (eg, schools, workplaces), community (eg, public restroom infrastructure), societal (eg, health care and insurance systems, national workforce/economic output), and ecosystem (eg, landfill waste) effects. The framework acknowledges that NCGUCs can be a manifestation of underlying biological dysfunction, while also leading to biological impacts (generation and exacerbation of health conditions, treatment side effects). Conclusion: NCGUCs confer a large, poorly understood burden to individuals and society. An evidence-base to describe the comprehensive burden is needed. Measurement of NCGUC burdens should incorporate multiple levels of well-being and social ecology, a life course perspective, and potential interactions between NCGUCs and genetics, sex, race, and gender. This approach would elucidate accumulated impacts and potential health inequities in experienced burdens. Uncovering the hidden burden of NCGUCs may draw attention and resources (eg, new research and improved treatments) to this important domain of health.
AB - Objective: To provide a conceptual framework to guide investigations into burdens of noncancerous genitourinary conditions (NCGUCs), which are extensive and poorly understood. Methods: The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop of diverse, interdisciplinary researchers and health professionals to identify known and hidden burdens of NCGUCs that must be measured to estimate the comprehensive burden. Following the meeting, a subgroup of attendees (authors of this article) continued to meet to conceptualize burden. Results: The Hidden Burden of Noncancerous Genitourinary Conditions Framework includes impacts across multiple levels of well-being and social ecology, including individual (ie, biologic factors, lived experience, behaviors), interpersonal (eg, romantic partners, family members), organizational/institutional (eg, schools, workplaces), community (eg, public restroom infrastructure), societal (eg, health care and insurance systems, national workforce/economic output), and ecosystem (eg, landfill waste) effects. The framework acknowledges that NCGUCs can be a manifestation of underlying biological dysfunction, while also leading to biological impacts (generation and exacerbation of health conditions, treatment side effects). Conclusion: NCGUCs confer a large, poorly understood burden to individuals and society. An evidence-base to describe the comprehensive burden is needed. Measurement of NCGUC burdens should incorporate multiple levels of well-being and social ecology, a life course perspective, and potential interactions between NCGUCs and genetics, sex, race, and gender. This approach would elucidate accumulated impacts and potential health inequities in experienced burdens. Uncovering the hidden burden of NCGUCs may draw attention and resources (eg, new research and improved treatments) to this important domain of health.
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U2 - 10.1016/j.urology.2021.08.040
DO - 10.1016/j.urology.2021.08.040
M3 - Article
C2 - 34536410
AN - SCOPUS:85117361969
SN - 0090-4295
VL - 166
SP - 39
EP - 49
JO - Urology
JF - Urology
ER -