Non-rigid dual respiratory and cardiac motion correction methods after, during, and before image reconstruction for 4D cardiac PET

Tao Feng, Jizhe Wang, George Fung, Benjamin Tsui

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Respiratory motion (RM) and cardiac motion (CM) degrade the quality and resolution in cardiac PET scans. We have developed non-rigid motion estimation methods to estimate both RM and CM based on 4D cardiac gated PET data alone, and compensate the dual respiratory and cardiac (R&C) motions after (MCAR), during (MCDR), and before (MCBR) image reconstruction. In all three R&C motion correction methods, attenuation-activity mismatch effect was modeled by using transformed attenuation maps using the estimated RM. The difference of using activity preserving and non-activity preserving models in R&C correction was also studied. Realistic Monte Carlo simulated 4D cardiac PET data using the 4D XCAT phantom and accurate models of the scanner design parameters and performance characteristics at different noise levels were employed as the known truth and for method development and evaluation. Results from the simulation study suggested that all three dual R&C motion correction methods provide substantial improvement in the quality of 4D cardiac gated PET images as compared with no motion correction. Specifically, the MCDR method yields the best performance for all different noise levels compared with the MCAR and MCBR methods. While MCBR reduces computational time dramatically but the resultant 4D cardiac gated PET images has overall inferior image quality when compared to that from the MCAR and MCDR approaches in the 'almost' noise free case. Also, the MCBR method has better noise handling properties when compared with MCAR and provides better quantitative results in high noise cases. When the goal is to reduce scan time or patient radiation dose, MCDR and MCBR provide a good compromise between image quality and computational times.

Original languageEnglish (US)
Pages (from-to)151-168
Number of pages18
JournalPhysics in medicine and biology
Issue number1
StatePublished - Dec 1 2015


  • cardiac PET
  • cardiac motion
  • image reconstruction
  • motion correction
  • respiratory motion

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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