TY - JOUR
T1 - Non-lymphoma hematological malignancies in systemic lupus erythematosus
AU - Lu, Mary
AU - Bernatsky, Sasha
AU - Ramsey-Goldman, Rosalind
AU - Petri, Michelle
AU - Manzi, Susan
AU - Urowitz, Murray B.
AU - Gladman, Dafna
AU - Fortin, Paul R.
AU - Ginzler, Ellen M.
AU - Yelin, Edward
AU - Bae, Sang Cheol
AU - Wallace, Daniel J.
AU - Jacobsen, Soren
AU - Dooley, Mary Anne
AU - Peschken, Christine A.
AU - Alarcón, Graciela S.
AU - Nived, Ola
AU - Gottesman, Lena
AU - Criswell, Lindsey A.
AU - Sturfelt, Gunnar
AU - Dreyer, Lene
AU - Lee, Jennifer L.
AU - Clarke, Ann E.
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.
AB - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.
KW - Cancer
KW - Malignancy
KW - Systemic lupus erythematosus
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U2 - 10.1159/000350165
DO - 10.1159/000350165
M3 - Article
C2 - 24107608
AN - SCOPUS:84885036201
SN - 0030-2414
VL - 85
SP - 235
EP - 240
JO - Oncology (Switzerland)
JF - Oncology (Switzerland)
IS - 4
ER -