Non-invasively evaluating therapeutic response of nanorod-mediated photothermal therapy on tumor angiogenesis

Ying Ying Bai, Shuyan Zheng, Liming Zhang, Kai Xia, Xihui Gao, Zi Hui Li, Cong Li, Nongyue He, Shenghong Ju

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Gold nanorod-mediated photothermal therapy has been widely explored for cancer treatment. However, timely evaluation of the therapeutic response is difficult as current diagnostic approaches are largely based on measurements of tumor volume. The present study developed a non-invasive imaging strategy to rapidly assess the efficacy of photothermal therapy in mice bearing human tumor xenografts. In this study, gold nanorods modified with carboxylated bovine serum albumin showed both anti-tumor and anti-angiogenesis effects under near-infrared laser irradiation. An ανβ3 integrin-targeted multi-modal nanoprobe, Dendrimer-arginine-glycine-aspartic acid (Den-RGD), was designed and intravenously injected into mice bearing tumor xenografts at 24 h after photothermal therapy. Magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging demonstrated that the Den-RGD not only visualized the tumors with high target-to-background ratio, but also showed the ability to evaluate the therapeutic response by monitoring the tumor neovasculature. Additionally, the target-to-background ratio on MRI and NIRF imaging correlated with the microvessel density in the Den-RGD groups. Immunofluorescence staining confirmed the targeting specificity of Den-RGD to the neovasculature at the tumor periphery. This dual-modal imaging method holds the promise of evaluating therapeutic efficacy in vivo. Nanomedicine provides a multi-functional platform for treatment of cancer and image-guided assessment of anti-cancer therapy.

Original languageEnglish (US)
Pages (from-to)3351-3360
Number of pages10
JournalJournal of Biomedical Nanotechnology
Volume10
Issue number11
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Angiogenesis
  • Magnetic resonance imaging
  • Nanoparticle
  • Near-Infrared imaging
  • Photothermal therapy
  • RGD peptides

ASJC Scopus subject areas

  • General Materials Science
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science
  • General Medicine

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