NON-INVASIVE QUANTITATION OF CORNEAL COPPER IN HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE)

M. Belkin; R. Zeimer; T. Chajek; G. Friedman; E. Melamed

doi:10.1016/S0140-6736(76)90217-8

NON-INVASIVE QUANTITATION OF CORNEAL COPPER IN HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE)

M. Belkin, R. Zeimer, T. Chajek, G. Friedman, E. Melamed

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Abstract

The corneal copper content was measured by X-ray excitation spectrometry in two controls and in seven patients with Wilson's disease. Patients who were treated irregularly or not treated at all showed a high corneal copper content. Those who were adequately treated had low levels, comparable to the controls. In one case the corneal copper content declined by 45%, after a course of dimercaprol. The corneal copper measured showed no correlation with the slit-lamp appearance of the Kayser-Fleischer ring. It is suggested that non-invasive X-ray excitation spectrometry can provide a fast and reliable method for the early diagnosis of Wilson's disease and for the objective evaluation of the efficacy of the treatment of this disease.

Original language	English (US)
Pages (from-to)	391-392
Number of pages	2
Journal	The Lancet
Volume	307
Issue number	7956
DOIs	https://doi.org/10.1016/S0140-6736(76)90217-8
State	Published - Feb 21 1976
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(76)90217-8

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title = "NON-INVASIVE QUANTITATION OF CORNEAL COPPER IN HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE)",

abstract = "The corneal copper content was measured by X-ray excitation spectrometry in two controls and in seven patients with Wilson's disease. Patients who were treated irregularly or not treated at all showed a high corneal copper content. Those who were adequately treated had low levels, comparable to the controls. In one case the corneal copper content declined by 45%, after a course of dimercaprol. The corneal copper measured showed no correlation with the slit-lamp appearance of the Kayser-Fleischer ring. It is suggested that non-invasive X-ray excitation spectrometry can provide a fast and reliable method for the early diagnosis of Wilson's disease and for the objective evaluation of the efficacy of the treatment of this disease.",

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T1 - NON-INVASIVE QUANTITATION OF CORNEAL COPPER IN HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE)

AU - Belkin, M.

AU - Zeimer, R.

AU - Chajek, T.

AU - Friedman, G.

AU - Melamed, E.

PY - 1976/2/21

Y1 - 1976/2/21

N2 - The corneal copper content was measured by X-ray excitation spectrometry in two controls and in seven patients with Wilson's disease. Patients who were treated irregularly or not treated at all showed a high corneal copper content. Those who were adequately treated had low levels, comparable to the controls. In one case the corneal copper content declined by 45%, after a course of dimercaprol. The corneal copper measured showed no correlation with the slit-lamp appearance of the Kayser-Fleischer ring. It is suggested that non-invasive X-ray excitation spectrometry can provide a fast and reliable method for the early diagnosis of Wilson's disease and for the objective evaluation of the efficacy of the treatment of this disease.

AB - The corneal copper content was measured by X-ray excitation spectrometry in two controls and in seven patients with Wilson's disease. Patients who were treated irregularly or not treated at all showed a high corneal copper content. Those who were adequately treated had low levels, comparable to the controls. In one case the corneal copper content declined by 45%, after a course of dimercaprol. The corneal copper measured showed no correlation with the slit-lamp appearance of the Kayser-Fleischer ring. It is suggested that non-invasive X-ray excitation spectrometry can provide a fast and reliable method for the early diagnosis of Wilson's disease and for the objective evaluation of the efficacy of the treatment of this disease.

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NON-INVASIVE QUANTITATION OF CORNEAL COPPER IN HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE)

Abstract

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