Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques

Peiying Liu, Lina F. Chalak, Hanzhang Lu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Because oxidative metabolism is the primary form of energy production in the brain, the amount of oxygen consumed by the brain, denoted by a physiological parameter termed cerebral metabolic rate of oxygen (CMRO2), represents a key marker for tissue viability and brain function. Quantitative assessment of cerebral oxygen metabolism in the neonate may provide an important marker in better understanding normal brain development and in making diagnosis and treatment decisions in neonatal brain injuries. Measurement of CMRO2 in humans has been a challenging task, particularly in neonates. Recently, several promising techniques have been proposed to quantify neonatal CMRO2 and the purpose of this article is to provide a technical review of these techniques. Among these, we will focus the review on the NIRS optic based methods and MRI methods which are non-invasive, have been applied in normal and sick newborns and show great potentials. Potential clinical prospects of CMRO2 techniques are discussed in the context of their advantages, challenges and limitations.

Original languageEnglish (US)
Pages (from-to)695-701
Number of pages7
JournalEarly Human Development
Issue number10
StatePublished - 2014


  • Cerebral metabolic rate of oxygen
  • Cerebral oxygen metabolism
  • Magnetic resonance imaging
  • Near-infrared spectroscopy
  • Neonates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques'. Together they form a unique fingerprint.

Cite this