Non-caloric artificial sweeteners and the microbiome: Findings and challenges

Jotham Suez, Tal Korem, Gili Zilberman-Schapira, Eran Segal, Eran Elinav

Research output: Contribution to journalArticlepeer-review


Non-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalGut Microbes
Issue number2
StatePublished - Apr 1 2015
Externally publishedYes


  • Artificial sweeteners
  • Diabetes
  • Glucose intolerance
  • Microbiome

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases


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