Nomenclature for renal replacement therapy in acute kidney injury: Basic principles

Mauro Neri, Gianluca Villa, Francesco Garzotto, Sean Bagshaw, Rinaldo Bellomo, Jorge Cerda, Fiorenza Ferrari, Silvia Guggia, Michael Joannidis, John Kellum, Jeong Chul Kim, Ravindra L. Mehta, Zaccaria Ricci, Alberto Trevisani, Silvio Marafon, William R. Clark, Jean Louis Vincent, Claudio Ronco, S. M. Bagshaw, A. BalducciI. Baldwin, F. Barbarigo, R. Bellomo, P. Braganó, J. Braunsky, F. Calletti, J. Cerda, L. Chawla, S. De Rosa, S. Di Somma, K. Doi, P. Dosil Rosende, M. Emmett, L. Fecondini, D. Galavotti, J. Kellum, F. Garzotto, A. Lorenzin, M. Neri, C. Ronco, S. L. Goldstein, G. Guadagni, P. Honoré, E. Hoste, K. Kashani, N. Katz, R. Kenley, J. Lannoy, A. Lewington, F. Mariano, on behalf of the Nomenclature Standardization Initiative (NSI) alliance

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


This article reports the conclusions of a consensus expert conference on the basic principles and nomenclature of renal replacement therapy (RRT) currently utilized to manage acute kidney injury (AKI). This multidisciplinary consensus conference discusses common definitions, components, techniques, and operations of the machines and platforms used to deliver extracorporeal therapies, utilizing a "machine-centric" rather than a "patient-centric" approach. We provide a detailed description of the performance characteristics of membranes, filters, transmembrane transport of solutes and fluid, flows, and methods of measurement of delivered treatment, focusing on continuous renal replacement therapies (CRRT) which are utilized in the management of critically ill patients with AKI. This is a consensus report on nomenclature harmonization for principles of extracorporeal renal replacement therapies. Devices and operations are classified and defined in detail to serve as guidelines for future use of terminology in papers and research.

Original languageEnglish (US)
Article number318
JournalCritical Care
Issue number1
StatePublished - Oct 10 2016


  • Clearance
  • Convection
  • CRRT efficiency
  • CRRT membranes
  • CRRT modalities
  • Diffusion
  • Dose
  • Terminology
  • Transmembrane pressure
  • Ultrafiltration

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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