Nociceptors lacking TRPV1 and TRPV2 have normal heat responses

C. Jeffery Woodbury, Melissa Zwick, Shuying Wang, Jeffrey J. Lawson, Michael J. Caterina, Martin Koltzenburg, Kathryn M. Albers, H. Richard Koerber, Brian M. Davis

Research output: Contribution to journalArticlepeer-review

218 Scopus citations


Vanilloid receptor 1 (TRPV1) has been proposed to be the principal heat-responsive channel for nociceptive neurons. The skin of both rat and mouse receives major projections from primary sensory afferents that bind the plant lectin isolectin B4 (IB4). The majority of IB4-positive neurons are known to be heat-responsive nociceptors. Previous studies suggested that, unlike rat, mouse IB4-positive cutaneous afferents did not express TRPV1 immunoreactivity. Here, multiple antisera were used to confirm that mouse and rat have different distributions of TRPV1 and that TRPV1 immunoreactivity is absent in heat-sensitive nociceptors. Intracellular recording in TRPV1-/- mice was then used to confirm that TRPV1 was not required for detecting noxious heat. TRPV1-/- mice had more heat-sensitive neurons, and these neurons had normal temperature thresholds and response properties. Moreover, in TRPV1 -/- mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel.

Original languageEnglish (US)
Pages (from-to)6410-6415
Number of pages6
JournalJournal of Neuroscience
Issue number28
StatePublished - Jul 14 2004


  • Capsaicin
  • Hypersensitivity
  • Nociception
  • Pain
  • Sensory neurons
  • Skin

ASJC Scopus subject areas

  • Medicine(all)


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