Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

James Meixiong; Lilian Basso; Xinzhong Dong; Nicolas Gaudenzio

doi:10.1016/j.tins.2020.01.001

Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

James Meixiong, Lilian Basso, Xinzhong Dong, Nicolas Gaudenzio

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

Original language	English (US)
Pages (from-to)	130-132
Number of pages	3
Journal	Trends in neurosciences
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.tins.2020.01.001
State	Published - Mar 2020

Keywords

MrgprB2/X2, skin
Nociceptive sensory neuron
mast cell
substance P

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.tins.2020.01.001

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title = "Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis",

abstract = "Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.",

keywords = "MrgprB2/X2, skin, Nociceptive sensory neuron, mast cell, substance P",

author = "James Meixiong and Lilian Basso and Xinzhong Dong and Nicolas Gaudenzio",

note = "Funding Information: This work was supported by grants from the European Research Council ( ERC-2018-STG #802041 ) and the INSERM ATIP-Avenir program (to N.G.) and NIH R01NS05479 1 (to X.D.). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = mar,

doi = "10.1016/j.tins.2020.01.001",

language = "English (US)",

volume = "43",

pages = "130--132",

journal = "Trends in neurosciences",

issn = "0166-2236",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

AU - Meixiong, James

AU - Basso, Lilian

AU - Dong, Xinzhong

AU - Gaudenzio, Nicolas

N1 - Funding Information: This work was supported by grants from the European Research Council ( ERC-2018-STG #802041 ) and the INSERM ATIP-Avenir program (to N.G.) and NIH R01NS05479 1 (to X.D.). Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/3

Y1 - 2020/3

N2 - Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

AB - Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

KW - MrgprB2/X2, skin

KW - Nociceptive sensory neuron

KW - mast cell

KW - substance P

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U2 - 10.1016/j.tins.2020.01.001

DO - 10.1016/j.tins.2020.01.001

M3 - Short survey

C2 - 32014258

AN - SCOPUS:85078805266

SN - 0166-2236

VL - 43

SP - 130

EP - 132

JO - Trends in neurosciences

JF - Trends in neurosciences

IS - 3

ER -

Nociceptor–Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

Abstract

Keywords

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