Abstract
Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.
Original language | English (US) |
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Pages (from-to) | 130-132 |
Number of pages | 3 |
Journal | Trends in neurosciences |
Volume | 43 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2020 |
Keywords
- MrgprB2/X2, skin
- Nociceptive sensory neuron
- mast cell
- substance P
ASJC Scopus subject areas
- General Neuroscience