No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Bharat Thyagarajan; Kristin E. Anderson; Aaron R. Folsom; David R. Jacobs; Charles F. Lynch; Archana Bargaje; Waseem Khaliq; Myron D. Gross

doi:10.1016/j.cdp.2006.07.002

No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Bharat Thyagarajan, Kristin E. Anderson, Aaron R. Folsom, David R. Jacobs, Charles F. Lynch, Archana Bargaje, Waseem Khaliq, Myron D. Gross

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

Original language	English (US)
Pages (from-to)	313-321
Number of pages	9
Journal	Cancer detection and prevention
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.cdp.2006.07.002
State	Published - 2006
Externally published	Yes

Keywords

Arg399Gln
BMI
Base excision repair
DNA repair
Double strand DNA repair
Genotype
INVADER assay
IWHS
Nested case control study
Paraffin embedded tissue
Polymorphisms
Postmenopausal breast cancer
Risk factors
Statistical analysis

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.cdp.2006.07.002

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@article{33aa2b4c77bb4c12a0d9933ba66fb5e7,

title = "No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study",

abstract = "Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.",

keywords = "Arg399Gln, BMI, Base excision repair, DNA repair, Double strand DNA repair, Genotype, INVADER assay, IWHS, Nested case control study, Paraffin embedded tissue, Polymorphisms, Postmenopausal breast cancer, Risk factors, Statistical analysis",

author = "Bharat Thyagarajan and Anderson, {Kristin E.} and Folsom, {Aaron R.} and Jacobs, {David R.} and Lynch, {Charles F.} and Archana Bargaje and Waseem Khaliq and Gross, {Myron D.}",

note = "Funding Information: This work was supported by NCI (Grant Number: RO1-CA39742). ",

year = "2006",

doi = "10.1016/j.cdp.2006.07.002",

language = "English (US)",

volume = "30",

pages = "313--321",

journal = "Cancer detection and prevention",

issn = "0361-090X",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk

T2 - Iowa Women's Health Study

AU - Thyagarajan, Bharat

AU - Anderson, Kristin E.

AU - Folsom, Aaron R.

AU - Jacobs, David R.

AU - Lynch, Charles F.

AU - Bargaje, Archana

AU - Khaliq, Waseem

AU - Gross, Myron D.

N1 - Funding Information: This work was supported by NCI (Grant Number: RO1-CA39742).

PY - 2006

Y1 - 2006

N2 - Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

AB - Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78-1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76-1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

KW - Arg399Gln

KW - BMI

KW - Base excision repair

KW - DNA repair

KW - Double strand DNA repair

KW - Genotype

KW - INVADER assay

KW - IWHS

KW - Nested case control study

KW - Paraffin embedded tissue

KW - Polymorphisms

KW - Postmenopausal breast cancer

KW - Risk factors

KW - Statistical analysis

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U2 - 10.1016/j.cdp.2006.07.002

DO - 10.1016/j.cdp.2006.07.002

M3 - Article

C2 - 16963196

AN - SCOPUS:33748747293

SN - 0361-090X

VL - 30

SP - 313

EP - 321

JO - Cancer detection and prevention

JF - Cancer detection and prevention

IS - 4

ER -

No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Abstract

Keywords

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