No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population

I. Kremer; M. Rietschel; M. Dobrusin; M. Mujaheed; I. Murad; M. Blanaru; I. Bannoura; D. J. Müller; T. G. Schulze; A. Reshef; S. Gathas; S. Schwab; D. Wildenauer; R. Bachner-Melman; R. H. Belmaker; W. Maier; R. P. Ebstein

No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population

I. Kremer, M. Rietschel, M. Dobrusin, M. Mujaheed, I. Murad, M. Blanaru, I. Bannoura, D. J. Müller, T. G. Schulze, A. Reshef, S. Gathas, S. Schwab, D. Wildenauer, R. Bachner-Melman, R. H. Belmaker, W. Maier, R. P. Ebstein

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	778-780
Number of pages	3
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	96
Issue number	6
State	Published - Dec 4 2000
Externally published	Yes

Keywords

Dopamine d3 receptor
Genetics
Haplotype relative risk
Linkage disequilibrium
Polymorphism
Schizophrenia

ASJC Scopus subject areas

Genetics(clinical)
Neuropsychology and Physiological Psychology
General Neuroscience

Cite this

Kremer, I., Rietschel, M., Dobrusin, M., Mujaheed, M., Murad, I., Blanaru, M., Bannoura, I., Müller, D. J., Schulze, T. G., Reshef, A., Gathas, S., Schwab, S., Wildenauer, D., Bachner-Melman, R., Belmaker, R. H., Maier, W., & Ebstein, R. P. (2000). No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(6), 778-780.

Kremer, I, Rietschel, M, Dobrusin, M, Mujaheed, M, Murad, I, Blanaru, M, Bannoura, I, Müller, DJ, Schulze, TG, Reshef, A, Gathas, S, Schwab, S, Wildenauer, D, Bachner-Melman, R, Belmaker, RH, Maier, W & Ebstein, RP 2000, 'No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 96, no. 6, pp. 778-780.

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abstract = "Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. (C) 2000 Wiley-Liss, Inc.",

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AU - Kremer, I.

AU - Rietschel, M.

AU - Dobrusin, M.

AU - Mujaheed, M.

AU - Murad, I.

AU - Blanaru, M.

AU - Bannoura, I.

AU - Müller, D. J.

AU - Schulze, T. G.

AU - Reshef, A.

AU - Gathas, S.

AU - Schwab, S.

AU - Wildenauer, D.

AU - Bachner-Melman, R.

AU - Belmaker, R. H.

AU - Maier, W.

AU - Ebstein, R. P.

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N2 - Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. (C) 2000 Wiley-Liss, Inc.

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No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population

Abstract

Keywords

ASJC Scopus subject areas

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