Abstract
AIM: To examine the effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptors on noxious stimulation-induced Fos expression in the rat spinal cord. METHODS: Formalin (2%) was injected sc into one hindpaw of the rat. Fos expression was exhibited by immunocytochemical technique. RESULTS: Two hours after sc formalin, Fos-like immunoreactive (FLI) neurons were distributed mainly in medial part of the lamina I and the outer lamina II of the ipsilateral dorsal horn. dl-2-Amino-5-phosphonovalerate (APV) administered intrathecally (10 μl, 0.01, 0.1, or 1 g · L-1) before injection of formalin into a hindpaw reduced the number of FLI neurons dose-dependently in the dorsal horn (P < 0.01), while 6, 7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX) (1 g · L-1) was ineffective. CONCLUSION: NMDA receptor mediated noxious stimulation-induced Fos expression in the rat spinal cord.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 506-509 |
| Number of pages | 4 |
| Journal | Acta Pharmacologica Sinica |
| Volume | 19 |
| Issue number | 6 |
| State | Published - Nov 1 1998 |
Keywords
- Formaldehyde
- Immunohistochemistry
- N-methyl-D-aspartate receptors
- Pain
- Proto-oncogene proteins c- fos
- Spinal cord
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)