Nitric oxide/redox-based signalling as a therapeutic target for penile disorders

Arthur L. Burnett, Biljana Musicki, Liming Jin, Trinity J. Bivalacqua

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Oxidative and/or nitrosative stress is implicated in the pathogeneses of assorted penile disorders of clinical significance, notably erectile dysfunction, priapism and penile fibrosis. It is becoming increasingly recognised that the generation and activity of reactive oxygen and nitrogen species in the penis influence vascular homeostasis of this organ, with adverse effects exerted at cellular and molecular levels. Furthermore, these elements may interact with molecular signalling pathways operating in the penis, modulating their functional roles. This interaction in particular suggests that by accessing molecular targets associated with oxidative/nitrosative stress in the penis, new pharmacotherapeutic approaches may be developed to promote normal erectile ability and preserve erectile tissue health. This notion pertains to, but also extends beyond, interventions which predictably target components of the nitric oxide-based signal transduction pathway for the on-demand treatment of erectile dysfunction. The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ.

Original languageEnglish (US)
Pages (from-to)445-457
Number of pages13
JournalExpert opinion on therapeutic targets
Volume10
Issue number3
DOIs
StatePublished - Jun 2006

Keywords

  • Erectile dysfunction
  • Guanylate cyclase activator
  • Nitric oxide synthase (NOS)
  • Nitrosative stress
  • Oxidative stress
  • Penile fibrosis
  • Phosphodiesterase type 5 inhibitor (PDE-5)
  • Priapism
  • Reactive nitrogen species (RNS)
  • Reactive oxygen species (ROS)
  • Signal transduction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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