Nitric oxide is a unique biological messenger molecule. It is produced by endothelial cells to mediate blood vessel relaxation; it mediates, in part, the immune functions of activated macrophages; and in the central and peripheral nervous system it serves as a neurotransmitter. In the nervous system, nitric oxide may regulate neurotransmitter release, it may play a key role in synaptic plasticity and morphogenesis, and it may regulate sexual and aggressive behavior. Under conditions of excessive formation, nitric oxide is emerging as an important neurotoxin.
- Endothelium-derived relaxing factor
- Long-term potentiation
- NADPH diaphorase
- Poly-ADP-ribose synthetase
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)