Nitric oxide signaling and the regulation of myocardial function

Mark T. Ziolo, Mark J. Kohr, Honglan Wang

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Issue number5
StatePublished - Nov 2008
Externally publishedYes


  • Excitation-contraction coupling
  • NOS
  • Peroxynitrite
  • Phospholamban
  • Ryanodine receptor
  • cGMP
  • l-type Ca channel

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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