Nitric oxide signaling and the regulation of myocardial function

Mark T. Ziolo; Mark J. Kohr; Honglan Wang

doi:10.1016/j.yjmcc.2008.07.015

Nitric oxide signaling and the regulation of myocardial function

Mark T. Ziolo, Mark J. Kohr, Honglan Wang

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.

Original language	English (US)
Pages (from-to)	625-632
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/j.yjmcc.2008.07.015
State	Published - Nov 2008
Externally published	Yes

Keywords

Excitation-contraction coupling
NOS
Peroxynitrite
Phospholamban
Ryanodine receptor
cGMP
l-type Ca channel

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/j.yjmcc.2008.07.015

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title = "Nitric oxide signaling and the regulation of myocardial function",

abstract = "Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.",

keywords = "Excitation-contraction coupling, NOS, Peroxynitrite, Phospholamban, Ryanodine receptor, cGMP, l-type Ca channel",

author = "Ziolo, {Mark T.} and Kohr, {Mark J.} and Honglan Wang",

note = "Funding Information: Supported by the American Heart Association (Pre-doctoral Fellowship 0715159B, MJK; Post-doctoral Fellowship, 0725560B HW) and the National Institutes of Health (R01HL079283, MTZ).",

year = "2008",

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doi = "10.1016/j.yjmcc.2008.07.015",

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volume = "45",

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journal = "Journal of Molecular and Cellular Cardiology",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Nitric oxide signaling and the regulation of myocardial function

AU - Ziolo, Mark T.

AU - Kohr, Mark J.

AU - Wang, Honglan

N1 - Funding Information: Supported by the American Heart Association (Pre-doctoral Fellowship 0715159B, MJK; Post-doctoral Fellowship, 0725560B HW) and the National Institutes of Health (R01HL079283, MTZ).

PY - 2008/11

Y1 - 2008/11

N2 - Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.

AB - Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.

KW - Excitation-contraction coupling

KW - NOS

KW - Peroxynitrite

KW - Phospholamban

KW - Ryanodine receptor

KW - cGMP

KW - l-type Ca channel

UR - http://www.scopus.com/inward/record.url?scp=55649084356&partnerID=8YFLogxK

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U2 - 10.1016/j.yjmcc.2008.07.015

DO - 10.1016/j.yjmcc.2008.07.015

M3 - Review article

C2 - 18722380

AN - SCOPUS:55649084356

SN - 0022-2828

VL - 45

SP - 625

EP - 632

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

IS - 5

ER -

Nitric oxide signaling and the regulation of myocardial function

Abstract

Keywords

ASJC Scopus subject areas

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