TY - JOUR
T1 - Nitric oxide in neurodegeneration
AU - Dawson, V. L.
AU - Dawson, T. M.
N1 - Funding Information:
VLD is supported by grants from USPHS NS33 142, the American Heart Association, Muscular Dystrophy Association and the Amyotrophic Lateral Sclerosis Association. TMD is an Established Investigator of the American Heart Association and is supported by grants from the USPHS NS33277, and the Paul Beeson Physician Scholars in Aging Research Program. Under an agreement between the Johns Hopkins University and Guilford Pharmaceuticals, TMD and VLD are entitled to a share of sales royalty received by the University from Guilford. TMD and the University also own Guilford stock, and the University stock is subject to certain restrictions under University policy. The terms of this arrangement are being managed by the University in accordance with its conflict of interest policies.
PY - 1998
Y1 - 1998
N2 - Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. NO mediates blood vessel relaxation by endothelium, immune activity of macrophages and neurotransmission of central and peripheral neurons. NO is produced from three NO Synthase (NOS) isoforms: Neuronal NOS (nNOS), endothelial NOS, and inducible NOS (iNOS). In the central nervous system, NO may play important roles in neurotransmitter release, neurotransmitter reuptake, neurodevelopment, synaptic plasticity, and regulation of gene expression. However, excessive production of NO following a pathologic insult can lead to neurotoxicity. NO plays a role in mediating neurotoxicity associated with a variety of neurologic disorders, including stroke, Parkinson's Disease, and HIV dementia.
AB - Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. NO mediates blood vessel relaxation by endothelium, immune activity of macrophages and neurotransmission of central and peripheral neurons. NO is produced from three NO Synthase (NOS) isoforms: Neuronal NOS (nNOS), endothelial NOS, and inducible NOS (iNOS). In the central nervous system, NO may play important roles in neurotransmitter release, neurotransmitter reuptake, neurodevelopment, synaptic plasticity, and regulation of gene expression. However, excessive production of NO following a pathologic insult can lead to neurotoxicity. NO plays a role in mediating neurotoxicity associated with a variety of neurologic disorders, including stroke, Parkinson's Disease, and HIV dementia.
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U2 - 10.1016/s0079-6123(08)63210-0
DO - 10.1016/s0079-6123(08)63210-0
M3 - Review article
C2 - 9932444
AN - SCOPUS:0031795484
SN - 0079-6123
VL - 118
SP - 215
EP - 229
JO - Progress in Brain Research
JF - Progress in Brain Research
ER -