Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

Ian Creese, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

204 Scopus citations


3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Jun 15 1979


  • Dopamine receptor
  • H-Apomorphine binding
  • H-Spiroperidol binding
  • Supeesensitivity

ASJC Scopus subject areas

  • Pharmacology


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