TY - JOUR
T1 - Night blindness during pregnancy and subsequent mortality among women in Nepal
T2 - Effects of vitamin A and β-carotene supplementation
AU - Christian, Parul
AU - West, Keith P.
AU - Khatry, Subarna K.
AU - Kimbrough-Pradhan, Elizabeth
AU - LeClerq, Steven C.
AU - Katz, Joanne
AU - Shrestha, Sharada Ram
AU - Dali, Sanu M.
AU - Sommer, Alfred
N1 - Funding Information:
Society for Blindness Prevention (Nepal Netra Jyoti Sangh), Kathmandu, Nepal, supported under Cooperative Agreement HRN-A-00-97-00015-00 between the Johns Hopkins University, Baltimore, MD, and the Office of Health and Nutrition, US Agency for International Development, assisted by Task Force Sight and Life, Roche, Basel, Switzerland, and the Sushil Kedia Foundation, Hariaun, Sarlahi, Nepal.
PY - 2000/9/15
Y1 - 2000/9/15
N2 - Night blindness due to vitamin A deficiency is common during pregnancy among women in Nepal. The authors assessed the risk of maternal death during and after a pregnancy with night blindness among women participating in a cluster-randomized, placebo-controlled vitamin A and β-carotene supplementation trial in Nepal from July 1994 to September 1997. Subjects were 877 women with night blindness and 9,545 women without night blindness during pregnancy. Women were followed from the time they declared that they were pregnant through the end of the study, representing a median follow-up of 90 weeks (interquartile range: 64-121 weeks). Mortality of night-blind women in the placebo group was 3,601 per 100,000 pregnancies. In comparison, the relative risk of dying among nonnight-blind women in the placebo group was 0.26 (95% confidence interval (Cl): 0.13, 0.55), and the relative risk among women with or without night blindness in the vitamin A/β-carotene group was 0.32 (95% Cl: 0.10, 0.91) and 0.18 (95% Cl: 0.09, 0.36), respectively. Night-blind women were five times (95% Cl: 2.20, 10.58) more likely to die from infections than were women who were not night blind. These findings show that night blindness during pregnancy is a risk factor of both short- and long-term mortality among women. Vitamin A/β-carotene supplementation ameliorates this risk to a large extent.
AB - Night blindness due to vitamin A deficiency is common during pregnancy among women in Nepal. The authors assessed the risk of maternal death during and after a pregnancy with night blindness among women participating in a cluster-randomized, placebo-controlled vitamin A and β-carotene supplementation trial in Nepal from July 1994 to September 1997. Subjects were 877 women with night blindness and 9,545 women without night blindness during pregnancy. Women were followed from the time they declared that they were pregnant through the end of the study, representing a median follow-up of 90 weeks (interquartile range: 64-121 weeks). Mortality of night-blind women in the placebo group was 3,601 per 100,000 pregnancies. In comparison, the relative risk of dying among nonnight-blind women in the placebo group was 0.26 (95% confidence interval (Cl): 0.13, 0.55), and the relative risk among women with or without night blindness in the vitamin A/β-carotene group was 0.32 (95% Cl: 0.10, 0.91) and 0.18 (95% Cl: 0.09, 0.36), respectively. Night-blind women were five times (95% Cl: 2.20, 10.58) more likely to die from infections than were women who were not night blind. These findings show that night blindness during pregnancy is a risk factor of both short- and long-term mortality among women. Vitamin A/β-carotene supplementation ameliorates this risk to a large extent.
KW - Maternal death
KW - Night blindness
KW - Pregnancy
KW - Vitamin A deficiency
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U2 - 10.1093/aje/152.6.542
DO - 10.1093/aje/152.6.542
M3 - Article
C2 - 10997544
AN - SCOPUS:0034666266
SN - 0002-9262
VL - 152
SP - 542
EP - 547
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 6
ER -