Nicotinic acetylcholine binding sites in Alzheimer's disease

Peter J. Whitehouse, Andrea M. Martino, Piero G. Antuono, Pedro R. Lowenstein, Joseph T. Coyle, Donald L. Price, Kenneth J. Kellar

Research output: Contribution to journalArticlepeer-review

397 Scopus citations


In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalBrain research
Issue number1
StatePublished - Apr 16 1986


  • Alzheimer's disease
  • acetylcholine
  • choline acetyltransferase
  • nicotinic cholinergic receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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