Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture

Yanfei Zhou; Xinbin Gu; Ebrahim Ashayeri; Renshu Zhang; Rajagopalan Sridhar

Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture

Yanfei Zhou, Xinbin Gu, Ebrahim Ashayeri, Renshu Zhang, Rajagopalan Sridhar

Research output: Contribution to journal › Article › peer-review

Abstract

The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treatment of many types of malignancies, including breast cancer. The effect of nicotine on doxorubicin toxicity was evaluated in MCF-7 and KB-3.1 cancer cell cultures. Nicotine partially inhibited doxorubicin toxicity towards MCF-7 and KB-3.1 cells, as judged by clonogenicity and flow cytometry assays. Flow cytometric analysis showed that

Original language	English (US)
Pages (from-to)	319-327
Number of pages	9
Journal	Journal of the National Medical Association
Volume	99
Issue number	4
State	Published - Apr 2007
Externally published	Yes

Keywords

Cancer
Chemotherapy
Doxorubicin
Nicotine

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture",

abstract = "The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treatment of many types of malignancies, including breast cancer. The effect of nicotine on doxorubicin toxicity was evaluated in MCF-7 and KB-3.1 cancer cell cultures. Nicotine partially inhibited doxorubicin toxicity towards MCF-7 and KB-3.1 cells, as judged by clonogenicity and flow cytometry assays. Flow cytometric analysis showed that ",

keywords = "Cancer, Chemotherapy, Doxorubicin, Nicotine",

author = "Yanfei Zhou and Xinbin Gu and Ebrahim Ashayeri and Renshu Zhang and Rajagopalan Sridhar",

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T1 - Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture

AU - Zhou, Yanfei

AU - Gu, Xinbin

AU - Ashayeri, Ebrahim

AU - Zhang, Renshu

AU - Sridhar, Rajagopalan

PY - 2007/4

Y1 - 2007/4

N2 - The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treatment of many types of malignancies, including breast cancer. The effect of nicotine on doxorubicin toxicity was evaluated in MCF-7 and KB-3.1 cancer cell cultures. Nicotine partially inhibited doxorubicin toxicity towards MCF-7 and KB-3.1 cells, as judged by clonogenicity and flow cytometry assays. Flow cytometric analysis showed that

AB - The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treatment of many types of malignancies, including breast cancer. The effect of nicotine on doxorubicin toxicity was evaluated in MCF-7 and KB-3.1 cancer cell cultures. Nicotine partially inhibited doxorubicin toxicity towards MCF-7 and KB-3.1 cells, as judged by clonogenicity and flow cytometry assays. Flow cytometric analysis showed that

KW - Cancer

KW - Chemotherapy

KW - Doxorubicin

KW - Nicotine

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SN - 0027-9684

VL - 99

SP - 319

EP - 327

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

IS - 4

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Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture

Abstract

Keywords

ASJC Scopus subject areas

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