Nicotine as a reinforcer in human subjects and laboratory animals

Jack E. Henningfield; Steven R. Goldberg

doi:10.1016/0091-3057(83)90405-7

Nicotine as a reinforcer in human subjects and laboratory animals

Jack E. Henningfield, Steven R. Goldberg

School of Medicine

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Results are summarized from 17 studies in which intravenous nicotine was evaluated in self-administration paradigms. Six species, ranging from the albino rat to the human, have been tested under a variety of schedules of reinforcement, and as a function of several pharmacologic manipulations. Under certain environmental conditions, it is clear that nicotine can serve as a reinforcer. However, nicotine differs from many other drugs of abuse in that the range of environmental conditions under which it serves as a reinforcer appears to be more restricted.

Original language	English (US)
Pages (from-to)	989-992
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/0091-3057(83)90405-7
State	Published - 1983

Keywords

Behavioral pharmacology
Cigarette smoking
Drug abuse
Nicotine
Reinforcement schedule
Self-administration

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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10.1016/0091-3057(83)90405-7

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AU - Goldberg, Steven R.

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AB - Results are summarized from 17 studies in which intravenous nicotine was evaluated in self-administration paradigms. Six species, ranging from the albino rat to the human, have been tested under a variety of schedules of reinforcement, and as a function of several pharmacologic manipulations. Under certain environmental conditions, it is clear that nicotine can serve as a reinforcer. However, nicotine differs from many other drugs of abuse in that the range of environmental conditions under which it serves as a reinforcer appears to be more restricted.

KW - Behavioral pharmacology

KW - Cigarette smoking

KW - Drug abuse

KW - Nicotine

KW - Reinforcement schedule

KW - Self-administration

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Nicotine as a reinforcer in human subjects and laboratory animals

Abstract

Keywords

ASJC Scopus subject areas

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