Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Experimental Medicine|
|State||Published - Nov 1 2004|
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