News from the nucleolus: rRNA gene expression

Barbara Sollner-Webb, Edward B. Mougey

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalTrends in biochemical sciences
Issue numberC
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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