Newer methods of labeling diagnostic agents with Tc-99m

Ronnie C. Mease, Carol Lambert

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of "3 + 1" complexes, the preparation and use of (99mTc[CO]3) + complexes for labeling biomolecules, the preparation of rhenium steroid inclusion complexes, improvements in both hydrazinonicotinamide labeling chemistry and in the preformed 99mTc complex method of labeling biomolecules, and new solid-phase separation techniques that may allow the isolation of high specific-activity radiopharmaceuticals in a clinical setting.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalSeminars in Nuclear Medicine
Issue number4
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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