TY - JOUR
T1 - New weapons to fight malaria transmission
T2 - A historical view
AU - Huang, Wei
AU - Cha, Sung Jae
AU - Jacobs-Lorena, Marcelo
N1 - Funding Information:
Research from our laboratory was supported by grant R01AI031478 from the National Institute of Allergy and Infectious Diseases (USA), from the Johns Hopkins Malaria Research Institute, and from the Bloomberg Philanthropies.
Publisher Copyright:
© 2022 The Authors. Entomological Research published by Entomological Society of Korea and John Wiley & Sons Australia, Ltd.
PY - 2022/5
Y1 - 2022/5
N2 - The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of parasite–mosquito interactions and coalesced in the development of novel tools namely, mosquito transgenesis and paratransgenesis. Here we provide a historical view of the development of these new tools and point to some remaining challenges for their implementation in the field.
AB - The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of parasite–mosquito interactions and coalesced in the development of novel tools namely, mosquito transgenesis and paratransgenesis. Here we provide a historical view of the development of these new tools and point to some remaining challenges for their implementation in the field.
KW - Biology, Ecology and Behavior
KW - Disease transmission and blood feeding arthropods
KW - Malaria transmission
KW - Medical and Veterinary Entomology
KW - Symbiotic relationships
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U2 - 10.1111/1748-5967.12585
DO - 10.1111/1748-5967.12585
M3 - Review article
C2 - 35846163
AN - SCOPUS:85129149392
SN - 1738-2297
VL - 52
SP - 235
EP - 240
JO - Entomological Research
JF - Entomological Research
IS - 5
ER -