New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Paola Conti; Alan P. Kozikowski

doi:10.1016/S0040-4039(00)00588-8

New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Paola Conti
, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	4053-4056
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)00588-8
State	Published - May 29 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)00588-8

Cite this

@article{858e358c3d454af7bad8aad9c9479cc8,

title = "New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist",

abstract = "A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.",

author = "Paola Conti and Kozikowski, \{Alan P.\}",

note = "Funding Information: We are indebted to the National Institute of Health (NS 35449) for support of this work. P.C. also acknowledges the CNR for a NATO fellowship. ",

year = "2000",

month = may,

day = "29",

doi = "10.1016/S0040-4039(00)00588-8",

language = "English (US)",

volume = "41",

pages = "4053--4056",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "21",

}

TY - JOUR

T1 - New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

AU - Conti, Paola

AU - Kozikowski, Alan P.

N1 - Funding Information: We are indebted to the National Institute of Health (NS 35449) for support of this work. P.C. also acknowledges the CNR for a NATO fellowship.

PY - 2000/5/29

Y1 - 2000/5/29

N2 - A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

AB - A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034729319

UR - https://www.scopus.com/pages/publications/0034729319#tab=citedBy

U2 - 10.1016/S0040-4039(00)00588-8

DO - 10.1016/S0040-4039(00)00588-8

M3 - Article

AN - SCOPUS:0034729319

SN - 0040-4039

VL - 41

SP - 4053

EP - 4056

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this