New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Paola Conti; Alan P. Kozikowski

doi:10.1016/S0040-4039(00)00588-8

New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Paola Conti, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	4053-4056
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)00588-8
State	Published - May 29 2000

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist",

abstract = "A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.",

author = "Paola Conti and Kozikowski, {Alan P.}",

note = "Funding Information: We are indebted to the National Institute of Health (NS 35449) for support of this work. P.C. also acknowledges the CNR for a NATO fellowship. ",

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AU - Conti, Paola

AU - Kozikowski, Alan P.

N1 - Funding Information: We are indebted to the National Institute of Health (NS 35449) for support of this work. P.C. also acknowledges the CNR for a NATO fellowship.

PY - 2000/5/29

Y1 - 2000/5/29

N2 - A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

AB - A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

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New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Abstract

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