TY - JOUR
T1 - New pediatric vision screener employing polarization-modulated, retinal-birefringence-scanning-based strabismus detection and bull's eye focus detection with an improved target system
T2 - Opto-mechanical design and operation
AU - Irsch, Kristina
AU - Gramatikov, Boris I.
AU - Wu, Yi Kai
AU - Guyton, David L.
N1 - Funding Information:
This work was supported in part by gifts from Robert and Maureen Feduniak, Dewey and Janet Gargiulo, David and Helen Leighton, Richard and Victoria Baks, Robert and Diane Levy, and by awards from the Hartwell Foundation (B. I. G., K. I.), Research to Prevent Blindness (D. L. G.), and the Knights Templar Eye Foundation (K. I.).
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014/6
Y1 - 2014/6
N2 - Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test for amblyopia's primary causes can detect strabismus only indirectly and inaccurately via assessment of the positions of external light reflections from the cornea, but they cannot detect the anatomical feature of the eyes where fixation actually occurs (the fovea). Our laboratory has been developing technology to detect true foveal fixation, by exploiting the birefringence of the uniquely arranged Henle fibers delineating the fovea using retinal birefringence scanning (RBS), and we recently described a polarization-modulated approach to RBS that enables entirely direct and reliable detection of true foveal fixation, with greatly enhanced signal-to-noise ratio and essentially independent of corneal birefringence (a confounding variable with all polarization-sensitive ophthalmic technology). Here, we describe the design and operation of a new pediatric vision screener that employs polarizationmodulated, RBS-based strabismus detection and bull's eye focus detection with an improved target system, and demonstrate the feasibility of this new approach.
AB - Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test for amblyopia's primary causes can detect strabismus only indirectly and inaccurately via assessment of the positions of external light reflections from the cornea, but they cannot detect the anatomical feature of the eyes where fixation actually occurs (the fovea). Our laboratory has been developing technology to detect true foveal fixation, by exploiting the birefringence of the uniquely arranged Henle fibers delineating the fovea using retinal birefringence scanning (RBS), and we recently described a polarization-modulated approach to RBS that enables entirely direct and reliable detection of true foveal fixation, with greatly enhanced signal-to-noise ratio and essentially independent of corneal birefringence (a confounding variable with all polarization-sensitive ophthalmic technology). Here, we describe the design and operation of a new pediatric vision screener that employs polarizationmodulated, RBS-based strabismus detection and bull's eye focus detection with an improved target system, and demonstrate the feasibility of this new approach.
KW - amblyopia
KW - birefringence
KW - cornea
KW - eye
KW - ophthalmology
KW - polarization-sensitive ophthalmic technology
KW - polarized light
KW - retina
KW - strabismus.
KW - vision screening
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U2 - 10.1117/1.JBO.19.6.067004
DO - 10.1117/1.JBO.19.6.067004
M3 - Article
C2 - 24911020
AN - SCOPUS:84911485715
SN - 1083-3668
VL - 19
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 6
M1 - 067004
ER -