New light on the integrin switch

Daniel J. Leahy

doi:10.1016/S0969-2126(02)00834-1

New light on the integrin switch

Daniel J. Leahy

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Recent structures of the integrin ectodomain and the cytoplasmic tail complex suggest a model for both "inside-out" and "outside-in" integrin signalling, whereby ligand binding and unclasping the cytoplasmic tails can shift integrin to a high-affinity form.

Original language	English (US)
Pages (from-to)	1152-1154
Number of pages	3
Journal	Structure
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/S0969-2126(02)00834-1
State	Published - Sep 2002
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0969-2126(02)00834-1

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title = "New light on the integrin switch",

abstract = "Recent structures of the integrin ectodomain and the cytoplasmic tail complex suggest a model for both {"}inside-out{"} and {"}outside-in{"} integrin signalling, whereby ligand binding and unclasping the cytoplasmic tails can shift integrin to a high-affinity form.",

author = "Leahy, \{Daniel J.\}",

year = "2002",

month = sep,

doi = "10.1016/S0969-2126(02)00834-1",

language = "English (US)",

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journal = "Structure",

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T1 - New light on the integrin switch

AU - Leahy, Daniel J.

PY - 2002/9

Y1 - 2002/9

N2 - Recent structures of the integrin ectodomain and the cytoplasmic tail complex suggest a model for both "inside-out" and "outside-in" integrin signalling, whereby ligand binding and unclasping the cytoplasmic tails can shift integrin to a high-affinity form.

AB - Recent structures of the integrin ectodomain and the cytoplasmic tail complex suggest a model for both "inside-out" and "outside-in" integrin signalling, whereby ligand binding and unclasping the cytoplasmic tails can shift integrin to a high-affinity form.

UR - https://www.scopus.com/pages/publications/0036710034

UR - https://www.scopus.com/pages/publications/0036710034#tab=citedBy

U2 - 10.1016/S0969-2126(02)00834-1

DO - 10.1016/S0969-2126(02)00834-1

M3 - Review article

C2 - 12220485

AN - SCOPUS:0036710034

SN - 0969-2126

VL - 10

SP - 1152

EP - 1154

JO - Structure

JF - Structure

IS - 9

ER -

New light on the integrin switch

Abstract

ASJC Scopus subject areas

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