New insights into ubiquitin E3 ligase mechanism

Christopher E. Berndsen, Cynthia Wolberger

Research output: Contribution to journalReview articlepeer-review

312 Scopus citations


E3 ligases carry out the final step in the ubiquitination cascade, catalyzing transfer of ubiquitin from an E2 enzyme to form a covalent bond with a substrate lysine. Three distinct classes of E3 ligases have been identified that stimulate transfer of ubiquitin and ubiquitin-like proteins through either a direct or an indirect mechanism. Only recently have the catalytic mechanisms of E3 ligases begun to be elucidated.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalNature Structural and Molecular Biology
Issue number4
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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