New insights into the causes of cancer

L. J. Helman; C. J. Thiele

doi:10.1016/S0031-3955(16)38075-0

New insights into the causes of cancer

L. J. Helman, C. J. Thiele

School of Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Recent advances in molecular biologic analysis have led to major new insights concerning the genetic mechanisms underlying the development of cancer. This article examines the current state of our understanding of the genetic basis underlying the possible mechanisms of carcinogenesis and metastasis. The nature of the genetic lesions found in some cancer-causing genes, cancer-inhibiting genes, growth factor genes, and metastasis genes is discussed, as is the impact that these may have on clinical oncology.

Original language	English (US)
Pages (from-to)	201-221
Number of pages	21
Journal	Pediatric clinics of North America
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/S0031-3955(16)38075-0
State	Published - Jan 1 1991

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0031-3955(16)38075-0

Cite this

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title = "New insights into the causes of cancer",

abstract = "Recent advances in molecular biologic analysis have led to major new insights concerning the genetic mechanisms underlying the development of cancer. This article examines the current state of our understanding of the genetic basis underlying the possible mechanisms of carcinogenesis and metastasis. The nature of the genetic lesions found in some cancer-causing genes, cancer-inhibiting genes, growth factor genes, and metastasis genes is discussed, as is the impact that these may have on clinical oncology.",

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AB - Recent advances in molecular biologic analysis have led to major new insights concerning the genetic mechanisms underlying the development of cancer. This article examines the current state of our understanding of the genetic basis underlying the possible mechanisms of carcinogenesis and metastasis. The nature of the genetic lesions found in some cancer-causing genes, cancer-inhibiting genes, growth factor genes, and metastasis genes is discussed, as is the impact that these may have on clinical oncology.

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New insights into the causes of cancer

Abstract

ASJC Scopus subject areas

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