New insights into nNOS regulation of vascular homeostasis

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


An important physiological response to changes in local or systemic oxygenation is the modulation of vascular tone, which is mediated in part by changes in the activities of the 3 NO synthase (NOS) isoforms. In arterial smooth muscle cells, acute hypoxia induces increased vascular tone, which is attenuated if hypoxia persists. In this issue of the JCI, Ward et al. demonstrate that changes in O2 concentration have effects on neuronal NOS enzymatic activity and gene expression that contribute to vascular homeostasis under conditions of acute and chronic hypoxia (see the related article beginning on page 3128).

Original languageEnglish (US)
Pages (from-to)2976-2978
Number of pages3
JournalJournal of Clinical Investigation
Issue number11
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Medicine(all)


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