New hepatocytes for toxicology?

Thomas Hartung; Laura Gribaldo

doi:10.1016/j.tibtech.2004.10.010

New hepatocytes for toxicology?

Thomas Hartung, Laura Gribaldo

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

In a recent article M.G. Sacco and co-workers described the establishment of immortalized untransformed transgenic hepatocyte (MMH-GH) cell lines, obtained from a cross between the AT/cytoMet and Hsp70/hGH transgenic mice. This strategy proved to be successful because the MMH-GH showed stability in culture and sensitivity to chemical exposure. Based on these results, the MMH-GH cell lines could prove to be a valid alternative cell-based assay for use in toxicological studies.

Original language	English (US)
Pages (from-to)	613-615
Number of pages	3
Journal	Trends in Biotechnology
Volume	22
Issue number	12
DOIs	https://doi.org/10.1016/j.tibtech.2004.10.010
State	Published - Dec 2004
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering

Access to Document

10.1016/j.tibtech.2004.10.010

Cite this

@article{407027d54721445586ddec6b6f22a128,

title = "New hepatocytes for toxicology?",

abstract = "In a recent article M.G. Sacco and co-workers described the establishment of immortalized untransformed transgenic hepatocyte (MMH-GH) cell lines, obtained from a cross between the AT/cytoMet and Hsp70/hGH transgenic mice. This strategy proved to be successful because the MMH-GH showed stability in culture and sensitivity to chemical exposure. Based on these results, the MMH-GH cell lines could prove to be a valid alternative cell-based assay for use in toxicological studies.",

author = "Thomas Hartung and Laura Gribaldo",

year = "2004",

month = dec,

doi = "10.1016/j.tibtech.2004.10.010",

language = "English (US)",

volume = "22",

pages = "613--615",

journal = "Trends in Biotechnology",

issn = "0167-7799",