New discoveries in the molecular landscape of bladder cancer

Ashish M. Kamat; Roger Li; Woonyoung Choi; J. E. Ferguson; Michael J. Metcalfe

doi:10.12688/f1000research.10031.1

New discoveries in the molecular landscape of bladder cancer

Ashish M. Kamat, Roger Li, Woonyoung Choi, J. E. Ferguson, Michael J. Metcalfe

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

We are currently on the cusp of exponential growth in the understanding of the molecular landscape of bladder cancer. Emerging data regarding the mutational burden and targetable genomic and protein alterations in bladder cancer have allowed us to tap into treatments directed toward specific molecular characteristics of bladder cancer. In parallel, these developments will enable us to better select patients for existing treatments of bladder cancer in a step toward personalized therapy. The present article reviews select discoveries that have advanced our understanding of bladder cancer and gives a glimpse of the exciting opportunities on the not-so-distant horizon.

Original language	English (US)
Article number	2875
Journal	F1000Research
Volume	5
DOIs	https://doi.org/10.12688/f1000research.10031.1
State	Published - 2016
Externally published	Yes

Keywords

Bladder
Carcinoma
Genomics
Sequencing

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.12688/f1000research.10031.1

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title = "New discoveries in the molecular landscape of bladder cancer",

abstract = "We are currently on the cusp of exponential growth in the understanding of the molecular landscape of bladder cancer. Emerging data regarding the mutational burden and targetable genomic and protein alterations in bladder cancer have allowed us to tap into treatments directed toward specific molecular characteristics of bladder cancer. In parallel, these developments will enable us to better select patients for existing treatments of bladder cancer in a step toward personalized therapy. The present article reviews select discoveries that have advanced our understanding of bladder cancer and gives a glimpse of the exciting opportunities on the not-so-distant horizon.",

keywords = "Bladder, Carcinoma, Genomics, Sequencing",

author = "Kamat, {Ashish M.} and Roger Li and Woonyoung Choi and Ferguson, {J. E.} and Metcalfe, {Michael J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Li R et al.",

year = "2016",

doi = "10.12688/f1000research.10031.1",

language = "English (US)",

volume = "5",

journal = "F1000Research",

issn = "2046-1402",

publisher = "F1000 Research Ltd.",

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TY - JOUR

T1 - New discoveries in the molecular landscape of bladder cancer

AU - Kamat, Ashish M.

AU - Li, Roger

AU - Choi, Woonyoung

AU - Ferguson, J. E.

AU - Metcalfe, Michael J.

PY - 2016

Y1 - 2016

N2 - We are currently on the cusp of exponential growth in the understanding of the molecular landscape of bladder cancer. Emerging data regarding the mutational burden and targetable genomic and protein alterations in bladder cancer have allowed us to tap into treatments directed toward specific molecular characteristics of bladder cancer. In parallel, these developments will enable us to better select patients for existing treatments of bladder cancer in a step toward personalized therapy. The present article reviews select discoveries that have advanced our understanding of bladder cancer and gives a glimpse of the exciting opportunities on the not-so-distant horizon.

AB - We are currently on the cusp of exponential growth in the understanding of the molecular landscape of bladder cancer. Emerging data regarding the mutational burden and targetable genomic and protein alterations in bladder cancer have allowed us to tap into treatments directed toward specific molecular characteristics of bladder cancer. In parallel, these developments will enable us to better select patients for existing treatments of bladder cancer in a step toward personalized therapy. The present article reviews select discoveries that have advanced our understanding of bladder cancer and gives a glimpse of the exciting opportunities on the not-so-distant horizon.

KW - Bladder

KW - Carcinoma

KW - Genomics

KW - Sequencing

UR - http://www.scopus.com/inward/record.url?scp=85010886962&partnerID=8YFLogxK

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U2 - 10.12688/f1000research.10031.1

DO - 10.12688/f1000research.10031.1

M3 - Review article

AN - SCOPUS:85010886962

SN - 2046-1402

VL - 5

JO - F1000Research

JF - F1000Research

M1 - 2875

ER -

New discoveries in the molecular landscape of bladder cancer

Abstract

Keywords

ASJC Scopus subject areas

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