New advances in the pathophysiologic and radiologic basis of the exstrophy spectrum

Ali Tourchi, Brian M. Inouye, Heather N. Di Carlo, Ezekiel Young, Joan Ko, John P. Gearhart

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The exstrophy-epispadias complex is a rare spectrum of anomalies affecting the genitourinary system, anterior abdominal wall, and pelvis. Recent advances in the repair of classic bladder exstrophy (CBE) and cloacal exstrophy (CE) have resulted in significant changes in outcomes of surgical management (including higher continence rate, fewer surgical complications, and better cosmesis) and health-related quality of life in these patients. These noteworthy changes resulted from advances in the pathophysiological and genetic backgrounds of this disease and better radiologic assessment of the three-dimensional anatomy of the bony pelvis and its musculature. A PubMed search was performed with the keyword exstrophy. The resulting literature pertaining to genetics, stem cells, imaging, tissue engineering, epidemiology, and endocrinology was reviewed. The following represents an overview of the advances in basic science understanding and imaging of the exstrophy-epispadias spectrum and discusses their possible and future effects on the management of CBE and CE.

Original languageEnglish (US)
Pages (from-to)212-218
Number of pages7
JournalJournal of pediatric urology
Issue number2
StatePublished - Apr 2014


  • Bladder exstrophy
  • Prenatal diagnosis
  • Radiology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology


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