Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies

Yi Jin, Eric S. Christenson, Lei Zheng, Keyu Li

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dismal five-year survival rate of less than 10%. Neutrophils are key components of the innate immune system, playing a pivotal role in the PDAC immune microenvironment. Areas covered: This review provides a comprehensive survey of the pivotal involvement of neutrophils in the tumorigenesis and progression of PDAC. Furthermore, it synthesizes preclinical and clinical explorations aimed at targeting neutrophils within the milieu of PDAC, subsequently proposing a conceptual framework to propel further inquiry focused on enhancing the therapeutic efficacy of PDAC through neutrophil-targeted strategies. PubMed and Web of Science databases were utilized for researching neutrophils in pancreatic cancer publications prior to 2024. Expert opinion: Neutrophils play roles in promoting tumor growth and metastasis in PDAC and are associated with poor prognosis. However, the heterogeneity and plasticity of neutrophils and their complex relationships with other immune cells and extracellular matrix also provide new insights for immunotherapy targeting neutrophils to achieve a better prognosis for PDAC.

Original languageEnglish (US)
JournalExpert review of clinical immunology
DOIs
StateAccepted/In press - 2024

Keywords

  • immunotherapy
  • neutrophil
  • Pancreatic ductal adenocarcinoma
  • tumor associated neutrophil
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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