Neutrophils in Homeostasis, Immunity, and Cancer

José Ángel Nicolás-Ávila, José M. Adrover, Andrés Hidalgo

Research output: Contribution to journalReview articlepeer-review

Abstract

Neutrophils were among the first leukocytes described and visualized by early immunologists. Prominent effector functions during infection and sterile inflammation classically placed them low in the immune tree as rapid, mindless aggressors with poor regulatory functions. This view is currently under reassessment as we uncover new aspects of their life cycle and identify transcriptional and phenotypic diversity that endows them with regulatory properties that extend beyond their lifetime in the circulation. These properties are revealing unanticipated roles for neutrophils in supporting homeostasis, as well as complex disease states such as cancer. We focus this review on these emerging functions in order to define the true roles of neutrophils in homeostasis, immunity, and disease.

Original languageEnglish (US)
Pages (from-to)15-28
Number of pages14
JournalImmunity
Volume46
Issue number1
DOIs
StatePublished - Jan 17 2017
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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