@article{d683638743554d7aa5d1af0465b264b2,
title = "Neurotropic virus infections as the cause of immediate and delayed neuropathology",
abstract = "A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.",
keywords = "Alphavirus, Bornavirus, Bunyavirus, Central nervous system, Flavivirus, Herpesvirus, Influenza virus, Neuroinfectiology, Neuropathology, Paramyxovirus, Picornavirus, Rhabdovirus, Virus infection",
author = "Martin Ludlow and Jeroen Kortekaas and Christiane Herden and Bernd Hoffmann and Dennis Tappe and Corinna Trebst and Griffin, {Diane E.} and Brindle, {Hannah E.} and Tom Solomon and Brown, {Alan S.} and {van Riel}, Debby and Wolthers, {Katja C.} and Dasja Pajkrt and Peter Wohlsein and Martina, {Byron E.E.} and Wolfgang Baumg{\"a}rtner and Verjans, {Georges M.} and Osterhaus, {Albert D.M.E.}",
note = "Funding Information: This study was in part supported by the Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) of the Ministry of Science and Culture of Lower Saxony, Germany (AO, WB, ML, GMV); ASKLEPIOS (AO, BEM); COMPARE project and has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under Grant Agreement No. 643476 (AO, WB), ZAPI (AO, WB, JK), SILVER (AO, BEM), VECTORIE (AO, BEM), FLUPLAN (AO); NIH R01 NS087539 and R01 NS038932 (DEG); the UK National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections (TS and HEB); the Seventh Framework Programme of the European Union AIPP for consortium AIROPIco under contract PIAPP-GA-2013-612308 (KCW); the Dutch Ministry of Economic Affairs project code WOT-01-003-015 (JK); Netherlands Organisation for Scientific Research (NWO, 91614115) (DR). Funding Information: This study was in part supported by the Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) of the Ministry of Science and Culture of Lower Saxony, Germany (AO, WB, ML, GMV); ASKLEPIOS (AO, BEM); COMPARE project and has received funding from the European Union{\^a}s Horizon 2020 research and innovation programme under Grant Agreement No. 643476 (AO, WB), ZAPI (AO, WB, JK), SILVER (AO, BEM), VECTORIE (AO, BEM), FLUPLAN (AO); NIH R01 NS087539 and R01 NS038932 (DEG); the UK National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections (TS and HEB); the Seventh Framework Programme of the European Union AIPP for consortium AIROPIco under contract PIAPP-GA-2013-612308 (KCW); the Dutch Ministry of Economic Affairs project code WOT-01-003-015 (JK); Netherlands Organisation for Scientific Research (NWO, 91614115) (DR). Publisher Copyright: {\textcopyright} 2015, The Author(s).",
year = "2016",
month = feb,
day = "1",
doi = "10.1007/s00401-015-1511-3",
language = "English (US)",
volume = "131",
pages = "159--184",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "2",
}