Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow; Jeroen Kortekaas; Christiane Herden; Bernd Hoffmann; Dennis Tappe; Corinna Trebst; Diane E. Griffin; Hannah E. Brindle; Tom Solomon; Alan S. Brown; Debby van Riel; Katja C. Wolthers; Dasja Pajkrt; Peter Wohlsein; Byron E.E. Martina; Wolfgang Baumgärtner; Georges M. Verjans; Albert D.M.E. Osterhaus

doi:10.1007/s00401-015-1511-3

Neurotropic virus infections as the cause of immediate and delayed neuropathology

Martin Ludlow, Jeroen Kortekaas, Christiane Herden, Bernd Hoffmann, Dennis Tappe, Corinna Trebst, Diane E. Griffin, Hannah E. Brindle, Tom Solomon, Alan S. Brown, Debby van Riel, Katja C. Wolthers, Dasja Pajkrt, Peter Wohlsein, Byron E.E. Martina, Wolfgang Baumgärtner, Georges M. Verjans, Albert D.M.E. Osterhaus

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

Original language	English (US)
Pages (from-to)	159-184
Number of pages	26
Journal	Acta neuropathologica
Volume	131
Issue number	2
DOIs	https://doi.org/10.1007/s00401-015-1511-3
State	Published - Feb 1 2016

Keywords

Alphavirus
Bornavirus
Bunyavirus
Central nervous system
Flavivirus
Herpesvirus
Influenza virus
Neuroinfectiology
Neuropathology
Paramyxovirus
Picornavirus
Rhabdovirus
Virus infection

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/s00401-015-1511-3

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Ludlow, M., Kortekaas, J., Herden, C., Hoffmann, B., Tappe, D., Trebst, C., Griffin, D. E., Brindle, H. E., Solomon, T., Brown, A. S., van Riel, D., Wolthers, K. C., Pajkrt, D., Wohlsein, P., Martina, B. E. E., Baumgärtner, W., Verjans, G. M., & Osterhaus, A. D. M. E. (2016). Neurotropic virus infections as the cause of immediate and delayed neuropathology. Acta neuropathologica, 131(2), 159-184. https://doi.org/10.1007/s00401-015-1511-3

Ludlow, M, Kortekaas, J, Herden, C, Hoffmann, B, Tappe, D, Trebst, C, Griffin, DE, Brindle, HE, Solomon, T, Brown, AS, van Riel, D, Wolthers, KC, Pajkrt, D, Wohlsein, P, Martina, BEE, Baumgärtner, W, Verjans, GM & Osterhaus, ADME 2016, 'Neurotropic virus infections as the cause of immediate and delayed neuropathology', Acta neuropathologica, vol. 131, no. 2, pp. 159-184. https://doi.org/10.1007/s00401-015-1511-3

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abstract = "A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.",

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AU - Verjans, Georges M.

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Neurotropic virus infections as the cause of immediate and delayed neuropathology

Abstract

Keywords

ASJC Scopus subject areas

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