Neurotransmitters in Anxiety

Rudolf Hoehn Saric

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


The most predictable anxiolytic effects of neurotransmitters are linked to the activation of a β-aminobutytic acid (GABA)—ergic subsystem associated with specific benzodiazepine receptors. Recent studies have indicated that subtypes of benzodiazepine receptors may be associated specifically with anxiolytic actions. Animal studies suggest that some forms of anxiety are mediated through the noradrenergic system, but a recent study testing this hypothesis confirmed it only partially. Other data implicate the serotonergic system in at least some types of anxiety. Currently the role of other neurotransmitters, such as dopamine, histamine, acetylcholine, and peptides, appears to be minimal. Clinical responses to drugs suggest the existence of at least two types of anxiety disorders representing perhaps different psychobiologic mechanisms.

Original languageEnglish (US)
Pages (from-to)735-742
Number of pages8
JournalArchives of general psychiatry
Issue number6
StatePublished - Jun 1982

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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