Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate

M. V. Johnston; R. Haddad; A. Carman-Young; J. T. Coyle

doi:10.1016/0165-3806(82)90140-7

Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate

M. V. Johnston, R. Haddad, A. Carman-Young, J. T. Coyle

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.

Original language	English (US)
Pages (from-to)	285-291
Number of pages	7
Journal	Developmental Brain Research
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0165-3806(82)90140-7
State	Published - Jul 1982
Externally published	Yes

Keywords

ferret
lissencephalic cortex
methylazoxymethanol acetate

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(82)90140-7

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title = "Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate",

abstract = "Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.",

keywords = "ferret, lissencephalic cortex, methylazoxymethanol acetate",

author = "Johnston, {M. V.} and R. Haddad and A. Carman-Young and Coyle, {J. T.}",

note = "Funding Information: This researchw as supportedb y USPHS Grants MH 26654, MH 00125 and DA 00266, and grants from the March of Dimes and the McKnight Foundation.",

year = "1982",

month = jul,

doi = "10.1016/0165-3806(82)90140-7",

language = "English (US)",

volume = "4",

pages = "285--291",

journal = "Developmental Brain Research",

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publisher = "Elsevier BV",

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TY - JOUR

T1 - Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate

AU - Johnston, M. V.

AU - Haddad, R.

AU - Carman-Young, A.

AU - Coyle, J. T.

N1 - Funding Information: This researchw as supportedb y USPHS Grants MH 26654, MH 00125 and DA 00266, and grants from the March of Dimes and the McKnight Foundation.

PY - 1982/7

Y1 - 1982/7

N2 - Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.

AB - Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.

KW - ferret

KW - lissencephalic cortex

KW - methylazoxymethanol acetate

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JO - Developmental Brain Research

JF - Developmental Brain Research

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ER -

Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate

Abstract

Keywords

ASJC Scopus subject areas

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