Neurotoxic Effects of Cisplatin Therapy

Thomas J. Walsh; Arthur W. Clark; Irma M. Parhad; William R. Green

doi:10.1001/archneur.1982.00510230045013

Neurotoxic Effects of Cisplatin Therapy

Thomas J. Walsh, Arthur W. Clark, Irma M. Parhad, William R. Green

School of Medicine

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127 Scopus citations

Abstract

Swelling of the optic disc and loss of tendon reflexes developed in a 31/2-yearold girl after 11 high-dose courses of cisplatin (cis-dichlorodiammine platinum [II]) therapy for recurrent sacrococcygeal teratoma. Postmortem examination demonstrated optic disc swelling; the spinal cord showed loss of myelinated fibers and gliosis of the dorsal columns. To our knowledge this case is the first in which the neuropathologic changes associated with cisplatin therapy have been demonstrated by postmortem examination.

Original language	English (US)
Pages (from-to)	719-720
Number of pages	2
Journal	Archives of neurology
Volume	39
Issue number	11
DOIs	https://doi.org/10.1001/archneur.1982.00510230045013
State	Published - Nov 1982

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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abstract = "Swelling of the optic disc and loss of tendon reflexes developed in a 31/2-yearold girl after 11 high-dose courses of cisplatin (cis-dichlorodiammine platinum [II]) therapy for recurrent sacrococcygeal teratoma. Postmortem examination demonstrated optic disc swelling; the spinal cord showed loss of myelinated fibers and gliosis of the dorsal columns. To our knowledge this case is the first in which the neuropathologic changes associated with cisplatin therapy have been demonstrated by postmortem examination.",

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AB - Swelling of the optic disc and loss of tendon reflexes developed in a 31/2-yearold girl after 11 high-dose courses of cisplatin (cis-dichlorodiammine platinum [II]) therapy for recurrent sacrococcygeal teratoma. Postmortem examination demonstrated optic disc swelling; the spinal cord showed loss of myelinated fibers and gliosis of the dorsal columns. To our knowledge this case is the first in which the neuropathologic changes associated with cisplatin therapy have been demonstrated by postmortem examination.

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Neurotoxic Effects of Cisplatin Therapy

Abstract

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