Swelling of the optic disc and loss of tendon reflexes developed in a 31/2-yearold girl after 11 high-dose courses of cisplatin (cis-dichlorodiammine platinum [II]) therapy for recurrent sacrococcygeal teratoma. Postmortem examination demonstrated optic disc swelling; the spinal cord showed loss of myelinated fibers and gliosis of the dorsal columns. To our knowledge this case is the first in which the neuropathologic changes associated with cisplatin therapy have been demonstrated by postmortem examination.
|Original language||English (US)|
|Number of pages||2|
|Journal||Archives of neurology|
|State||Published - Nov 1982|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology