Neurosyphilis Masquerading as Herpes Encephalitis

Krishna Dass, Shmuel Shoham, Daniel R. Lucey

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Classic presentations of neurosyphilis, such as tabes dorsalis and general paresis, are rare today. Instead, neurosyphilis can present with a spectrum of diverse clinical manifestations. Therefore, neurosyphilis should be considered in the differential diagnosis of all patients with unexplained neurologic deficit or encephalitis. We report a patient who had a nonbloody spinal fluid venereal disease research laboratory titer of 1:32, but presented with a clinical syndrome, MRI findings, and an electroencephalogram (EEG) pattern consistent with herpes simplex encephalitis. Admission spinal fluid PCR for herpes simplex viruses 1 and 2 was negative in 2 reference laboratories.

Original languageEnglish (US)
Pages (from-to)30-31
Number of pages2
JournalInfectious Diseases in Clinical Practice
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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