Neurostimulation in the treatment of epilepsy

Gregory K. Bergey

doi:10.1016/j.expneurol.2013.04.004

Neurostimulation in the treatment of epilepsy

Gregory K. Bergey

School of Medicine

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

There is increased interest in neurostimulation as a treatment for drug-resistant epilepsy. Two large pivotal trials have recently been completed, one using bilateral anterior thalamic stimulation and another employing closed loop responsive therapy of the brain. These are potential additions to the therapeutic options for neurostimulation in addition to already approved vagus nerve stimulation. This review will address the principles of the various types of neurostimulation, the results of the pivotal trials and the important considerations for interpreting the results of these trials which differ from trials of antiepileptic drugs.

Original language	English (US)
Pages (from-to)	87-95
Number of pages	9
Journal	Experimental Neurology
Volume	244
DOIs	https://doi.org/10.1016/j.expneurol.2013.04.004
State	Published - Jun 2013

Keywords

Anterior thalamic
Closed loop
Epilepsy
Neurostimulation
Responsive neurostimulation
Vagus nerve stimulation

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2013.04.004

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AB - There is increased interest in neurostimulation as a treatment for drug-resistant epilepsy. Two large pivotal trials have recently been completed, one using bilateral anterior thalamic stimulation and another employing closed loop responsive therapy of the brain. These are potential additions to the therapeutic options for neurostimulation in addition to already approved vagus nerve stimulation. This review will address the principles of the various types of neurostimulation, the results of the pivotal trials and the important considerations for interpreting the results of these trials which differ from trials of antiepileptic drugs.

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KW - Responsive neurostimulation

KW - Vagus nerve stimulation

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Neurostimulation in the treatment of epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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