Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors

P. Escher; E. Lacazette; M. Courtet; A. Blindenbacher; L. Landmann; C. Bezakova; K. C. Lloyd; U. Mueller; H. R. Brenner

doi:10.1126/science.1108258

Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors

P. Escher, E. Lacazette, M. Courtet, A. Blindenbacher, L. Landmann, C. Bezakova, K. C. Lloyd, U. Mueller, H. R. Brenner

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96 Scopus citations

Abstract

The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

Original language	English (US)
Pages (from-to)	1920-1923
Number of pages	4
Journal	Science
Volume	308
Issue number	5730
DOIs	https://doi.org/10.1126/science.1108258
State	Published - Jun 24 2005
Externally published	Yes

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title = "Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors",

abstract = "The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.",

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AU - Escher, P.

AU - Lacazette, E.

AU - Courtet, M.

AU - Blindenbacher, A.

AU - Landmann, L.

AU - Bezakova, C.

AU - Lloyd, K. C.

AU - Mueller, U.

AU - Brenner, H. R.

PY - 2005/6/24

Y1 - 2005/6/24

N2 - The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

AB - The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

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Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors

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