Neuropsychological Effects of Depression and Age in an Elderly Sample: A Confirmatory Study

Deborah A. King, Christopher Cox, Jeffrey M. Lyness, Eric D. Caine

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Few well-controlled studies have directly examined the relationship of age and depression with neuropsychological function while at the same time examining the possible influence of general medical illness. Toward this end, 44 elderly patients with unipolar major depression were compared with 30 nondepressed controls with a range of neuropsychological tests. The depressed patients evidenced a broad base of deficits relative to controls, as well as more rapid declines with increasing age on tests of complex psychomotor function, copying, and perceptual integration. Overall level of general medical illness had minimal influence on neuropsychological test performance in either group. In light of recent reports contradictory to the findings presented here, the importance of participant selection variables in neuropsychological studies of late-life depression is discussed.

Original languageEnglish (US)
Pages (from-to)399-408
Number of pages10
Issue number3
StatePublished - Jul 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology


Dive into the research topics of 'Neuropsychological Effects of Depression and Age in an Elderly Sample: A Confirmatory Study'. Together they form a unique fingerprint.

Cite this