Neuropsychological deficits in huntington's disease gene carriers and correlates of early "conversion"

Jason Brandt, Anjeli B. Inscore, Julianna Ward, Barnett Shpritz, Adam Rosenblatt, Russell L. Margolis, Christopher A. Ross

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The authors examined whether the baseline cognitive functioning of 21 clinically normal huntingtin mutation carriers who developed manifest Huntington's disease on follow-up differed from hat of 49 mutation carriers who remain asymptomatic over the same period in a longitudinal study. One hundred thirty-four gene-negative off spring of Huntington s disease patients were studied as well. Overall, there were no differences in cognitive test performance among the three groups. However, "converters" who developed signs of Huntington's disease within 8.6 years demonstrated poorer performance on the Wisconsin Card Sorting Test at baseline. People with the Huntington s disease mutation who are carefully examined neurologically and found to be asymptomatic have, at most, very minimal problem-solving impairment, and only if they are within a few years ofclinical onset.

Original languageEnglish (US)
Pages (from-to)466-472
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Nov 2008

ASJC Scopus subject areas

  • General Medicine


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